The Sedgley Glove Gun was one of the goofiest projects actually funded by the US military during WWII. Designed for the Navy, it was basically a leather gardening glove with a single shot .38 S&W pistol attached to the back (the original patent calls for a .410 shotshell, but this was changed for unknown reasons). A plunger fired the gun, and the idea was literally that the user would make a fist and punch his adversary, shooting them in the process. Depending on which numbers you believe, somewhere between 52 and 200 of these were actually made, and there is no confirmed record of any actually being used in combat. There are suggestions that the OSS also used them, but these are also unconfirmed.
We had the privilege to examine this mint-condition example at the National World War II Museum in New Orleans, and very much appreciate the opportunity!
US Patent 2,423,448 (S.M. Haight, “Fist Gun”, filed February 29, 1944)